ACREME Fortnightly Webinar 22 June 2023

Join the Australian Centre of Research Excellence in Malaria Elimination (ACREME) at the fortnightly webinars.

"Monoclonal antibodies against Plasmodium vivax Apical Membrane Antigen-1; revealing the mechanism of action of AMA1" with Dr Lee Yeoh

We have recently developed monoclonal antibodies specific to Plasmodium vivax AMA1. These have shown extremely high reactivity to AMA1 via functional and inhibition assays in vitro. These antibodies are promising therapeutics in themselves, but are also exceptionally useful for their capability in dissecting the mechanism of PvAMA1's function. Recent data suggest that PvAMA1 potentially facilitates invasion via two independent interactions.

"Adherence to 14-day radical cure for Plasmodium vivax malaria in Papua, Indonesia: a mixed-methods study" with Annisa Rahmalia

Reducing the risk of recurrent Plasmodium vivax malaria is critical for malaria control and elimination. Primaquine (PQ) is the only widely available drug against P. vivax dormant liver stages, but is recommended as a 14-day regimen, which can undermine adherence to a complete course of treatment.

Adherence to malaria treatment was a socio-culturally embedded process during which patients (re-)evaluated the characteristics of the medicines in relation to the course of the illness, their past experiences with illness, and the perceived benefits of the treatment. Structural barriers that hinder the process of patient adherence are crucial to consider in the development and rollout of effective malaria treatment policies.

Recordings will be available on the ACREME website.