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Understanding Postbiotics: Guardians of Gut Health

The Australian Dietary Guidelines recommend consuming at least five servings of vegetables and two servings of fruit daily. Shockingly, 92% and 50% of Australian adults fail to meet their recommended daily vegetable and fruit intake, respectively. This deficiency leads to poor nutritional health and burdens the healthcare system

substantially, costing Australia more than $195 billion annually. The gut microbiome is indispensable in food metabolism, nutrient absorption, health maintenance, disease prevention, and treatment. Specifically, the composition of an individual's gut microbiome affects the body’s ability to absorb nutrients. As a result, even if someone eats a healthy diet or meets their daily nutritional requirements, their altered gut microbiota may prevent them from absorbing the nutrients in their food.

Whilst microbiome-targeted dietary interventions such as prebiotics and probiotics are readily available and can be promising, their efficacy relies largely on the plasticity of the gut microbiome. However, restoring an altered gut microbiome is exceptionally challenging due to the influence of environmental factors (e.g., diet, antibiotics) and biological factors (e.g., individual variations, diseases, and race). This is where the concept of postbiotics offers a novel approach to improving nutrition and health outcomes. Postbiotics are the signaling molecules produced by trillions of microorganisms living in our gut.

This presentation will showcase the latest advancements in the gut microbiome and postbiotics research that pertain to gut health, featuring studies from The GutBiotics Lab. We will focus on strategies for optimising the production of beneficial postbiotics in the gut through appropriate dietary choices and the use of nutritional supplements.

Presenter: Dr. Deep Jyoti Bhuyan

Dr. Deep Jyoti Bhuyan is a Research Support Program Fellow, International Engagement Coordinator, and Higher Degree Research Coordinator at the NICM Health Research Institute (NICM HRI) at Western Sydney University (WSU). He leads The GutBiotics Lab, which comprises 16 PhD and MRes students, along with two Research Assistants at NICM HRI. The lab focuses on the therapeutic roles of the microbiome, postbiotics, and Australian native plants. He established NICM HRI’s first gut microbiome-virology laboratory and a next-generation genome sequencing facility.

His research has been instrumental in a recent paradigm shift in gut health, particularly in understanding the impact of postbiotics on health, shaping future clinical and translational research. Dr Bhuyan has produced 62 publications, including 57 journal articles and five invited book chapters. He has presented at 40 conferences, delivering 11 invited talks and two keynote presentations. Dr Bhuyan’s research on postbiotics was featured in over 160 media outlets, including The Conversation, ABC News/Radio and BBC Brazil, reaching more than 39 million readers. He has appeared in more than ten television interviews, which received global media coverage. His research on postbiotics has also won several awards, including the 2023 Marcus Blackmore Outstanding Contribution to Research award from Complementary Medicines Australia, the 2022 People’s Choice award at the Western Sydney University Research Impact Competition and the 2020 NICM HRI Excellence award as an Early Career Researcher. He also provides scientific expertise to various organizations and scientific journals focused on the gut microbiome.