ACREME Fortnightly Webinar 7 December 2022

Join the Australian Centre of Research Excellence in Malaria Elimination (ACREME) at the fortnightly webinars.

A novel IgG3 allotype identified in women from Papua New Guinea that modulates Fc effector functions with Professor Stephen Rogerson

Allotypes are variant forms of immunoglobulin molecules that can alter antibody functions such as engagement of complement or Fc receptors found on immune cells. In pregnant women from Papua New Guinea we identified a novel IgG3 allotype that is common in women of Sepik origin, and characterised its association with pregnancy malaria. Using variants of a monoclonal antibody including the new allotype, we examined the effects of the mutations on antibody functions.

Recordings will be available on the ACREME website.