BDG LifeSciences, operating in India as BDG LifeSciences (OPC) Pvt. Ltd., and in collaboration with BBR PTY LTD. in Australia, is a distinguished bioinformatics company specializing in the facilitation of workshops, training sessions, innovative research projects, and online courses within the realm of bioinformatics technologies. Established in 2010, the company has been actively engaged in the field, holding registrations under the Ministry of MSME (Micro, Small, and Medium Enterprises), Government of India, with the registration number UDYAM-UP-01-0019151. Over the years, BDG LifeSciences has successfully imparted knowledge to a diverse array of participants worldwide, including students, scientists, faculty members, professors, and corporate executives.

As we believe in a different way of learning which is HANDS-ON PRACTICAL SESSIONS our workshops are unique because participants perform on their own computer/laptop on software/servers, so it is 100 % practical application of technology which is the main reason of BEING A LEADER in the sector for the last 14 years.

To view the pictures of our previous events click here-1 and click here-2. To view, the listing of upcoming events kindly click here and our previous workshops can be viewed here. To view the video feedback of our previous events kindly visit our YouTube Channel

Innovation & creativity is an integral part of BDG Lifesciences (OPC) Pvt. Ltd and we always launch new programs on the newest topics. Now advancing in the technology we have launched a 5-day complete hands-on Online Workshop in Chimeric Antigen Receptor (CAR) T-cells for Cancer Immunotherapy.

INTRODUCTION

Chimeric Antigen Receptor (CAR) T-cell therapy is a type of immunotherapy that uses a patient’s own genetically modified T-cells to find and kill cancer cells. Over the recent years CAR T-cell Therapy has generated substantial excitement among oncologists. They have shown the ability to eradicate tumors in people with advanced leukemias and lymphomas and to keep the cancer at bay for many years. Six CAR T-cell therapies have been approved by FDA since 2017. Computational design of CAR is essential for better treatment outcomes.This program will be an extensive hands-on training program in which everyday 150 minutes of live session will be conducted by Dr Shahul Hameed and participants will run the processes (insilico) on their own computer systems with complete learning of this revolutionary technology.

Video recording of each session will be provided at the end of the session to give the user a unique learning experience. On successful completion of the course participation certificate will be awarded.

TOPICS

Tumor specific &Tumor Associated T-cell antigens and epitopes.
Identifying tumor antigens by screening a tumorcDNA expression library against cancer sera.
Selection of scFvAntibody. Fragments for CAR-T Cell Therapy from Phage Display Libraries.
Structure-guided engineering of the affinity and specificity of CARs against Tumor antigens.
Computationally Guided Design of Single-Chain Variable Fragment.
Chimeric Antigen Receptor Design & Construction.
Intracellular signaling pathways of the CARs.
Machine Learning in CAR sequence Optimization and Design.
Generating synthetic CAR using deep learning.
CRISPR CAS in CAR T-cell therapy: knock-in and immune-checkpoint.
Universal CAR T-cells

OUTCOME OF THIS PROGRAM: Participants will learn

Basic principles of chimeric antigen receptor design for CAR T-cell therapy.
The participant will be able to design Chimeric Antigen Receptor for a given tumor.
Optimize CAR for better expression on T-cells and Tumor cell killing activity.
Reduce Toxicity of CAR T-cell therapy.

TARGET AUDIENCE

Student: Bachelor, Masters, PhD, MBBS, MD students as well as Faculty and Professors from Microbiology, Biochemistry, Biotechnology, Immunology, Medicine, Pharmacy, Pharmaceutical Chemistry, Biomedical Technology, Genetics, Bioinformatics, Plant Science and Life Sciences.Professionals: Resident Doctors, Biotechnology, Bioinformatics, Medicine and Pharmaceutical scientists from industry, academia, and regulatory agencies. Hands-on exercises will be performed individually using software tools on your own laptops. (no prior experience required).

RESOURCE PERSON

Dr. Shahul Hameed is a researcher and his research involves developing CRISPR based gene therapy for Muscular dystrophy and Sickle Cell Anaemia. He is also involved in the development of novel delivery systems for gene therapy. His research interest extends to design of mRNA based therapeutics and design of Artificial Intelligence based Digital health & Imaging tools. In Collaboration with Dystrophy Annihilation Research Trust, his lab was involved in gene editing of DMD gene for development of CRISPR based therapeutics. [Nov 2018 to Aug 2022].

He has worked as Senior Assistant Professor at B.S. Abdur Rahman Crescent University, Chennai and earlier at Bannari Amman Institute of Technology, Erode. He was involved in teaching biotechnology subjects like Protein Engineering, Genomics and Proteomics, Structural Biology, Pharmaceutical Biotechnology, Genetic Engineering and Chemical Reaction Engineering to students. His research work involved Drug Design against S100A4 oncoprotein. Further development of Machine Learning based tools for predicting thermodynamic stability of enzyme mutants. He was selected through ERASMUS to conduct workshops on drug design and protein engineering at University of Nottingham, UK.

He is a PhD in Biological Sciences from Indian Institute of Science(IISc), Bangalore. At IISc, his research work involved Protein Engineering and Structural Characterization of the engineered mutants using Nuclear magnetic resonance spectroscopy and other biophysical methods. His research work also involved characterization of Protein-Protein interactions using experimental techniques, like NMR and Mass spectrometry, genetic engineering and Computer simulations.

He did his postdoctoral training at Tata Institute of Fundamental Research, Mumbai. There his work involved development of novel NMR techniques to study huge protein complexes. His work also involved Cloning, Protein Expression and Purification of motor proteins.

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