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Please join us for a seminar by Professor Philip De Jager on 'Modeling regulatory networks and neurodegenerative disease trajectories at cellular resolution in the human brain’.

Professor Philip De Jager is the Weil-Granat Professor of Neurology at Columbia University Medical Center, where he is the Chief of the Division of Neuroimmunology. The division consists of the Columbia Multiple Sclerosis Center and the Center for Translational & Computational Neuroimmunology. He focuses on characterizing and modulating the immune system in inflammatory and neurodegenerative diseases. He also serves as the Deputy Director of the Taub Institute for Research on Alzheimer’s Disease (AD) and the Aging Brain. P

Using a deep integration of computational methods and rigorous molecular biology, he is defining the sequence of molecular events that leads a healthy immune system to become dysfunctional and ultimately engage the central nervous system as a target. He has delineated molecular networks and cellular communities in the CNS that lead to AD, with an emphasis on defining the basic biology of aging human microglia. His new Brain-MAAP Initiative expands these efforts by generating large-scale multi-omic data in a spatially registered manner from human brain.

Finally, an ongoing effort of the laboratory centers on the resident immune cells of the brain: microglia. Poorly characterized in humans, we have just completed a third version of a single cell transcriptomic atlas of human microglial states, delineating the extent of their heterogeneity across brain regions and diseases. Further, we have developed a chemical and genetic toolkit to recapitulate microglia states in vitro to enable functional characterization of this cell type and therapeutic development.

Overall, the goal of Dr. De Jager’s work as a clinician-scientist is to apply modern methods of human immunology, genomics, molecular genetics and computational biology to the understanding and treatment of common neuroinflammatory and neurodegenerative diseases.

Following the seminar there will be drinks and snacks.

Seminar Date and Time: Monday 12 February 2024, from 3:30pm - 4:30pm AEDT.

Seminar Location: Lecture Theatre (502). Brain Mind Centre, 94 Mallett Street, Camperdown

Join Remotely: For those unable to attend in person, you may join online via Zoom: https://uni-sydney.zoom.us/j/82089031207

ID: 820 8903 1207

Guests are welcome and are encouraged to attend in-person.

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